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Australian Drinking Water Guidelines
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  • Australian Drinking Water Guidelines
  • Copyright
  • Table of updates
  • Contents
  • Figures
  • Tables
  • Boxes
  • Introduction
    • Chapter 1: Introduction
      • 1.1 Guiding principles
      • 1.2 About the Guidelines
        • 1.2.1 Scope of the Guidelines
        • 1.2.2 Purpose of the Guidelines
        • 1.2.3 Structure of the Guidelines
      • 1.3 Water quality characteristics
        • 1.3.1 Introduction
        • 1.3.2 Health-based targets
        • 1.3.3 Microbial health-based targets
        • 1.3.4 Physical and chemical guideline values
        • 1.3.5 Radiological screening and reference values
      • 1.4 Community consultation
      • 1.5 Development of the Guidelines
        • 1.5.1 Acknowledgments
      • 1.6 Future revisions of the Guidelines
      • 1.7 References
  • Part 1: Management of Drinking Water Quality
    • Chapter 2: Framework for Management of Drinking Water Quality: overview
      • 2.1 A preventive strategy from catchment to consumer
      • 2.2 Structure of the Framework
      • 2.3 Benefits of the Framework
      • 2.4 The need for multi-agency involvement
      • 2.5 Applying the Framework
      • 2.6 Correlations of the Framework with other systems
    • Chapter 3: Framework for Management of Drinking Water Quality: the twelve elements
      • 3.1 Commitment to drinking water quality management (element 1)
        • 3.1.1 Drinking water quality policy
        • 3.1.2 Regulatory and formal requirements
        • 3.1.3 Engaging stakeholders
      • 3.2 Assessment of the drinking water supply system (element 2)
        • 3.2.1 Water supply system analysis
        • 3.2.2 Assessment of water quality data
        • 3.2.3 Hazard identification and risk assessment
      • 3.3 Preventive measures for drinking water quality management (element 3)
        • 3.3.1 Preventive measures and multiple barriers
        • 3.3.2 Critical control points
      • 3.4 Operational procedures and process control (element 4)
        • 3.4.1 Operational procedures
        • 3.4.2 Operational monitoring
        • 3.4.3 Corrective action
        • 3.4.4 Equipment capability and maintenance
        • 3.4.5 Materials and chemicals
      • 3.5 Verification of drinking water quality (element 5)
        • 3.5.1 Drinking water quality monitoring
        • 3.5.2 Consumer satisfaction
        • 3.5.3 Short-term evaluation of results
        • 3.5.4 Corrective action
      • 3.6 Management of incidents and emergencies (element 6)
        • 3.6.1 Communication
        • 3.6.2 Incident and emergency response protocols
      • 3.7 Employee awareness and training (element 7)
        • 3.7.1 Employee awareness and involvement
        • 3.7.2 Employee training
      • 3.8 Community involvement and awareness (element 8)
        • 3.8.1 Community consultation
        • 3.8.2 Communication
      • 3.9 Research and development (element 9)
        • 3.9.1 Investigative studies and research monitoring
        • 3.9.2 Validation of processes
        • 3.9.3 Design of equipment
      • 3.10 Documentation and reporting (element 10)
        • 3.10.1 Management of documentation and records
        • 3.10.2 Reporting
      • 3.11 Evaluation and audit (element 11)
        • 3.11.1 Long-term evaluation of results
        • 3.11.2 Audit of drinking water quality management
      • 3.12 Review and continual improvement (element 12)
        • 3.12.1 Review by senior executive
        • 3.12.2 Drinking water quality management improvement plan
      • 3.13 References
    • Chapter 4: Framework for the Management of Drinking Water Quality: application to small water supplies
      • 4.1 Introduction
      • 4.2 Applying the Framework
        • 4.2.1 Assessment of the drinking water supply
        • 4.2.2 Preventive measures for drinking water quality management
        • 4.2.3 Implementation of operational procedures and process control
        • 4.2.4 Verification of drinking water quality
      • 4.3 Individual household supplies
      • 4.4 Reference
  • Part 2: Description of Water Quality
    • Chapter 5: Microbial Quality of Drinking Water (Updated 2022)
      • 5.1 Introduction
      • 5.2 Microorganisms in drinking water
      • 5.3 Assessing microbial risk
      • 5.4 Enteric pathogens
        • 5.4.1 Enteric pathogens of concern in drinking water
        • 5.4.2 Contamination of source waters with enteric pathogens
        • 5.4.3 Management of risk from enteric pathogens
      • 5.5 Opportunistic pathogens
      • 5.6 Cyanobacteria
      • 5.7 Nuisance organisms
        • 5.7.1 Organisms causing taste and odour problems
        • 5.7.2 Organisms causing colour problems
        • 5.7.3 Deposits due to iron and manganese bacteria
        • 5.7.4 Corrosion problems due to iron and sulphur bacteria
        • 5.7.5 Problems caused by large numbers of microorganisms
      • 5.8 References
    • Chapter 6: Physical and Chemical Quality of Drinking Water
      • 6.1 Introduction
      • 6.2 Physical quality of drinking water
        • 6.2.1 An overview of physical characteristics
        • 6.2.2 Approach used in derivation of guidelines values for physical characteristics
      • 6.3 Chemical quality of drinking water
        • 6.3.1 Inorganic chemicals
        • 6.3.2 Organic compounds (Revised 2011)
        • 6.3.3 Approach used in derivation of guideline values for chemicals
      • 6.4 Differences between Australian and WHO guideline values
      • 6.5 National and international guideline values (2016)
      • 6.6 References
    • Chapter 7: Radiological Quality of Drinking Water (Updated 2022)
      • 7.1 Introduction
      • 7.2 Sources of radiation in the environment and in drinking water
      • 7.3 Health effects of radiation
      • 7.4 Exposure to radiation
      • 7.5 Units of radioactivity and radiation dose measurement
        • 7.5.1 Units of radioactivity and radiation dose
        • 7.5.2 Converting intake to radiation dose
        • 7.5.3 Average dose of radiation
      • 7.6 Approach for derivation of reference levels and screening values for radionuclides
        • 7.6.1 System for radiation protection
        • 7.6.2 Estimation of the dose from radionuclides in water
        • 7.6.3 Estimation of risk from low-level radiation
        • 7.6.4 Reference levels and screening values for drinking water
        • 7.6.5 Application of reference levels
        • 7.6.6 Remedial measures
      • 7.7 References
    • Chapter 8: Drinking Water Treatment Chemicals (Revised 2006)
      • 8.1 Introduction
      • 8.2 Scope and limit of application of this chapter
      • 8.3 Overview of chemical treatment processes
        • 8.3.1 Control of algae
        • 8.3.2 Coagulation and flocculation
        • 8.3.3 Adsorption
        • 8.3.4 Softening
        • 8.3.5 Oxidation
        • 8.3.6 Disinfection
        • 8.3.7 Adjustment of pH
        • 8.3.8 Addition of buffering capacity
        • 8.3.9 Corrosion inhibition
      • 8.4 Public health measures
        • 8.4.1 Fluoridation
      • 8.5 Assessment of Chemicals acceptable for use in drinking water treatment (revised 2016)
        • 8.5.1 Chemicals assessed prior to 2004
        • 8.5.2 New water treatment chemicals
      • 8.6 Quality assurance for drinking water treatment chemicals
        • 8.6.1 Risks associated with drinking water chemicals
        • 8.6.2 Managing risks
        • 8.6.3 Specifications for the supply of drinking water treatment chemicals
      • 8.7 Monitoring and analytical requirements
      • 8.8 Contaminants in drinking water treatment chemicals
      • 8.9 Useful contacts
      • 8.10 References
  • Part 3: Monitoring
    • Chapter 9: Overview of monitoring (Revised 2021)
      • 9.1 Introduction
      • 9.2 Monitoring overview
        • 9.2.1 Monitoring priorities
        • 9.2.2 Principles of monitoring frequency
        • 9.2.3 Catchment-to-consumer monitoring
      • 9.3 Developing a monitoring program
      • 9.4 Operational monitoring
        • 9.4.1 Operational characteristics
        • 9.4.2 Target criteria
        • 9.4.3 Critical limits at critical control points
        • 9.4.4 Corrective action
        • 9.4.5 Operational monitoring frequency
        • 9.4.6 Chlorination as a critical control point: an example
      • 9.5 Verification of drinking water quality
        • 9.5.1 Monitoring consumer satisfaction
        • 9.5.2 Drinking water quality monitoring
      • 9.6 Water quality issues beyond the point of supply
      • 9.7 Investigative studies and research monitoring
      • 9.8 Validation of barrier performance
      • 9.9 Incident and emergency response monitoring
      • 9.10 Reliability of monitoring data
        • 9.10.1 Sample integrity
        • 9.10.2 Methods
        • 9.10.3 Detection limits
        • 9.10.4 Measurement uncertainty
        • 9.10.5 Field testing
      • 9.11 Monitoring advice for small, remote or community-managed water supplies
      • 9.12 Assessing the significance of short-term exceedances of health-based guideline values
      • 9.13 References
    • Chapter 10: Monitoring for specific characteristics in drinking water (Updated 2022)
      • 10.1 Introduction
      • 10.2 Assessing safety: short-term evaluation of monitoring
        • 10.2.1 Short-term evaluation of operational monitoring
        • 10.2.2 Short-term evaluation of drinking water quality monitoring
      • 10.3 Assessing performance: long-term evaluation of monitoring
        • 10.3.1 Long-term evaluation of microbial performance
        • 10.3.2 Long-term evaluation of health-based chemical performance
        • 10.3.3 Long-term evaluation of aesthetic performance
        • 10.3.4 Long-term evaluation of consumer satisfaction
        • 10.3.5 Improvement plan
        • 10.3.6 Performance reporting
        • 10.3.7 Summary of guideline values for microbial, chemical and physical characteristics
        • 10.3.8 Summary of reference levels and screening values for radiological characteristics
      • 10.4 Reference
  • Part 4: Information sheets
    • 1. Disinfection
      • 1.1: Introduction to water treatment
      • 1.2: Overview of disinfection
      • 1.3: Disinfection with chlorine
      • 1.4: Chloramines
      • 1.5: Disinfection with chlorine dioxide
      • 1.6: Disinfection with ozone
      • 1.7: Disinfection with ultraviolet light
      • 1.8: Other disinfectants
    • 2. Sampling
      • 2.1: Sampling Information – handling requirements and preservation
      • 2.2: Radiological monitoring and assessment of performance (updated 2022)
    • 3. Statistics
      • 3.1: Statistics – Visualising data
      • 3.2: Statistics – Assessing data
      • 3.3: Statistics – Statistical principles
      • 3.4: Statistics – Control charts and trends
      • 3.5: Number of samples required
      • 3.6: Guidance for issuing and lifting boil water advisories
      • Attachments
  • Part 5: Fact sheets
    • Microorganisms
      • Microbial indicators
        • Bacteroides
        • Coliphages
        • Clostridium perfringens
        • Escherichia coli
        • Heterotrophic plate counts
        • Intestinal enterococci
        • Thermotolerant coliforms
        • Total coliforms
      • Bacteria
        • Aeromonas
        • Burkholderia pseudomallei
        • Campylobacter
        • Escherichia coli (E. coli) (pathogenic)
        • Helicobacter pylori
        • Klebsiella
        • Legionella
        • Mycobacterium
        • Pseudomonas aeruginosa
        • Salmonella
        • Shigella
        • Vibrio
        • Yersinia
      • Protozoa
        • Acanthamoeba
        • Blastocystis
        • Cryptosporidium
        • Cyclospora
        • Giardia
        • Naegleria fowleri
      • Cyanobacteria and their toxins
        • Cyanobacteria and their toxins
        • Cylindrospermopsin
        • Microcystins
        • Nodularin
        • Saxitoxins
      • Viruses
        • Adenovirus
        • Enterovirus
        • Hepatitis viruses
        • Norovirus
        • Rotavirus
    • Physical and chemical characteristics
      • Acephate
      • Acrylamide
      • Aldicarb
      • Aldrin and Dieldrin
      • Aluminium
      • Ametryn
      • Amitraz
      • Amitrole
      • Ammonia
      • Antimony
      • Arsenic
      • Asbestos
      • Asulam
      • Atrazine
      • Azinphos-methyl
      • Barium
      • Benomyl
      • Bentazone
      • Benzene
      • Beryllium
      • Bioresmethrin
      • Boron
      • Bromacil
      • Bromate
      • Bromoxynil
      • Cadmium
      • Captan
      • Carbaryl
      • Carbendazim/Thiophanate-methyl
      • Carbofuran
      • Carbon tetrachloride
      • Carboxin
      • Carfentrazone-ethyl
      • Chloral hydrate (Trichloroacetaldehyde)
      • Chlorantraniliprole
      • Chlordane
      • Chlorfenvinphos
      • Chloride
      • Chlorinated furanones
      • Chlorine
      • Chlorine dioxide, Chlorite, Chlorate
      • Chloroacetic acids: chloroacetic acid, dichloroacetic acid (DCA), trichloroacetic acid (TCA)
      • Chlorobenzene
      • Chloroketones
      • Chlorophenols
      • Chloropicrin
      • Chlorothalonil
      • Chlorpyrifos
      • Chlorsulfuron
      • Chromium
      • Clopyralid
      • Colour (True)
      • Copper
      • Cyanide
      • Cyanogen chloride
      • Cyfluthrin, Beta-cyfluthrin
      • Cypermethrin isomers
      • Cyprodinil
      • 2,4-D [(2,4-Dichlorophenoxy) acetic acid]
      • DDT (1,1,1-trichloro-di-(4-chlorophenyl) ethane)
      • Deltamethrin
      • Diazinon
      • Dicamba
      • Dichlorobenzenes
      • Dichloroethanes: 1,1-dichloroethane, 1,2-dichloroethane
      • Dichloroethenes: 1,1-dichloroethene (1,1-DCE), 1,2-dichloroethene (1,2-DCE)
      • Dichloromethane (methylene chloride)
      • 1,3-Dichloropropene
      • Dichlorprop/Dichlorprop-P
      • Dichlorvos
      • Diclofop-methyl
      • Dicofol
      • Diflubenzuron
      • Dimethoate
      • Diquat (ion), Diquat dibromide
      • Dissolved oxygen
      • Disulfoton
      • Diuron
      • 2,2-DPA
      • Endosulfan
      • Endothal
      • Epichlorohydrin
      • EPTC
      • Esfenvalerate
      • Ethion
      • Ethoprophos
      • Ethylbenzene
      • Ethylenediamine tetraacetic acid (EDTA)
      • Etridiazole
      • Fenamiphos
      • Fenarimol
      • Fenchlorphos
      • Fenitrothion
      • Fenthion
      • Fenvalerate
      • Fipronil
      • Flamprop-methyl
      • Fluometuron
      • Fluoride
      • Flupropanate
      • Formaldehyde
      • Glyphosate
      • Haloacetonitriles
      • Haloxyfop
      • Hardness (as calcium carbonate)
      • Heptachlor and heptachlor epoxide
      • Hexachlorobutadiene
      • Hexazinone
      • Hydrogen sulfide, Sulfide
      • Imazapyr
      • Iodine, Iodide
      • Iprodione
      • Iron
      • Lanthanum
      • Lead
      • Lindane
      • Maldison (Malathion)
      • Mancozeb
      • Manganese
      • MCPA
      • Mercury
      • Metaldehyde
      • Metham
      • Methidathion
      • Methiocarb
      • Methomyl
      • Methyl bromide
      • Metiram
      • Metolachlor/s-Metolachlor
      • Metribuzin
      • Metsulfuron-methyl
      • Mevinphos
      • Molinate
      • Molybdenum
      • Monochloramine
      • Naphthalophos
      • Napropamide
      • Nicarbazin
      • Nickel
      • Nitrate and nitrite
      • Nitrilotriacetic acid (NTA)
      • N-Nitrosodimethylamine (NDMA)
      • Norflurazon
      • Omethoate
      • Organotins: dialkyltins, tributyltin oxide
      • Oryzalin
      • Oxamyl
      • Paraquat
      • Parathion
      • Parathion-methyl
      • Pebulate
      • Pendimethalin
      • Pentachlorophenol
      • Per-fluoroalkyl and poly-fluoroalkyl substances (PFAS)
      • Permethrin
      • pH
      • Picloram
      • Piperonyl butoxide
      • Pirimicarb
      • Pirimiphos methyl
      • Plasticisers
      • Polihexanide
      • Polycyclic aromatic hydrocarbons (PAHs)
      • Profenofos
      • Promecarb
      • Propachlor
      • Propanil
      • Propargite
      • Propazine
      • Propiconazole
      • Propyzamide
      • Pyrasulfotole
      • Pyrazophos
      • Pyroxsulam
      • Quintozene
      • Radionuclides, Specific Alpha and Beta Emitting
      • Radium (radium-226 and radium-228)
      • Radon-222
      • Selenium
      • Silica
      • Silver
      • Simazine
      • Sodium
      • Spirotetramat
      • Styrene (vinylbenzene)
      • Sulfate
      • Sulprofos
      • Taste and Odour
      • Temephos
      • Temperature
      • Terbacil
      • Terbufos
      • Terbuthylazine
      • Terbutryn
      • Tetrachloroethene
      • Thiobencarb
      • Thiometon
      • Thiram
      • Tin
      • Toltrazuril
      • Toluene
      • Total dissolved solids
      • Triadimefon
      • Trichlorfon
      • Trichlorobenzenes
      • 1,1,1-Trichloroethane
      • Trichloroethylene (TCE)
      • Triclopyr
      • Trifluralin
      • Trihalomethanes (THMs)
      • Turbidity
      • Uranium
      • Vernolate
      • Vinyl chloride
      • Xylenes
      • Zinc
    • Drinking water treatment chemicals
      • Aluminium chlorohydrate
      • Aluminium sulfate (alum)
      • Ammonia
      • Ammonium sulfate
      • Calcium hydroxide
      • Calcium hypochlorite
      • Calcium oxide
      • Carbon, granulated activated
      • Carbon, powdered activated
      • Chlorine
      • Copper sulfate
      • Ferric chloride
      • Ferric sulfate
      • Hydrochloric acid
      • Hydrofluorosilicic acid
      • Hydrogen peroxide
      • Hydroxylated ferric sulfate
      • Ozone
      • Polyacrylamide
      • Polyaluminium chloride
      • Polyaluminium silica sulfates
      • Polydiallyldimethylammonium chloride
      • Potassium permanganate
      • Sodium aluminate
      • Sodium bicarbonate
      • Sodium carbonate
      • Sodium fluoride
      • Sodium fluorosilicate
      • Sodium hexametaphosphate
      • Sodium hydroxide
      • Sodium hypochlorite
      • Sodium silicate
      • Sodium tripolyphosphate
      • Sulfuric acid
      • Zinc orthophosphate
  • Appendices
    • Appendix 1: Additional guidance
      • A1.1 Introduction
      • A1.2 Water supply system analysis
      • A1.3 Assessment of water quality data
      • A1.4 Hazard identification
      • A1.5 Risk assessment
      • A1.6 Preventive measures and multiple barriers
      • A1.7 Critical control points
      • A1.8 Chlorination as an example of a critical control point
      • A1.9 References
    • Appendix 2: Further sources of information on drinking water quality management
      • A2.1 Drinking water quality management - general
      • A2.2 Catchment management and source water protection
      • A2.3 Groundwater protection
      • A2.4 Risk assessment and management
      • A2.5 System analysis and management process control and optimisation
      • A2.6 Monitoring and verification
      • A2.7 Materials and chemicals
      • A2.8 Incident and emergency management
      • A2.9 Employee training and awareness
      • A2.10 Research and development
      • A2.11 Documentation and reporting
      • A2.12 Community consultation and communication
      • A2.13 Hazard analysis and critical control point (HACCP)
      • A2.14 Quality management continuous improvement
      • A2.15 Reference web sites
    • Appendix 3: Derivation of microbial treatment targets for enteric pathogens
      • A3.1 Introduction to Quantitative Microbial Risk Assessment (QMRA)
      • A3.2 Adopting the QMRA approach in the Guidelines
      • A3.3 QMRA framework for the calculation of log₁₀ reduction values (LRVs)
      • A3.4 Defining the health outcome target
      • A3.5 Selection of reference pathogens
      • A3.6 Level of reference pathogen contamination in Australian source waters
      • A3.7 Consumption volume of unheated (unboiled) water per person per day
      • A3.8 Dose response relationships
      • A3.9 Disability Adjusted Life Years (DALY) burden per case
      • A3.10 Calculation of LRVs using the QMRA framework
      • A3.11 Interpretation of calculated LRVs for practical treatment guidance
      • A3.12 Understanding log₁₀ reductions
      • A3.13 References
  • Glossary
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Australian Drinking Water Guidelines 6 2011, v3.9

  • Go back to NHMRC website
On this page
  • Guideline
  • Related chemicals
  • Human risk statement
  • General description
  • Typical values in Australian drinking water
  • Treatment of drinking water
  • Measurement
  • History of the health values
  • Health considerations
  • Derivation of the health-based guideline
  • References
  1. Part 5: Fact sheets
  2. Physical and chemical characteristics

Cyprodinil

(endorsed 2011)

Guideline

Based on human health concerns, cyprodinil in drinking water should not exceed 0.09 mg/L.

Related chemicals

Cyprodinil (CAS 121552-61-2) belongs to the anilinopyrimidine class of chemicals. Another pesticide in this class is pyrimethanil (Tomlin 2006).

Human risk statement

With good water quality management practices, the exposure of the general population is expected to be well below levels that may cause health concerns.

If present in drinking water as a result of a spillage or through misuse, cyprodinil would not be a health concern unless the concentration exceeded 0.09 mg/L. Excursions above this level would need to occur over a significant period to be a health concern, as the health-based guideline is based on long-term effects.

With good water quality management practices, pesticides should not be detected in source waters used for drinking water supplies. Persistent detection of pesticides may indicate inappropriate use or accidental spillage and investigation is required in line with established procedures in the risk management plan for the particular water source.

General description

Uses: Cyprodinil is a fungicide for the control of black spot in apples and pears; the control of blossom blight and brown rot in apricots, peaches, plums and nectarines; and, in combination with fludioxonil, the control of grey mould in grapes.

There are registered products that contain cyprodinil in Australia. These are intended for professional use and are available as water-dispersible granules to be applied as concentrated or dilute solutions, commonly using air blast, misters or hand-held equipment. Data on currently registered products are available from the Australian Pesticides and Veterinary Medicines Authority.

Exposure sources: The main source of public exposure to cyprodinil is residues in food. Residue levels in food produced according to good agricultural practice are generally low.

Agricultural use of cyprodinil may potentially lead to contamination of source waters through processes such as run-off, spray drift or entry into groundwater.

Typical values in Australian drinking water

No occurrence data for cyprodinil in Australian waters were found.

Treatment of drinking water

No data on drinking water treatment removal efficiency were found for cyprodinil.

Measurement

Cyprodinil in water can be analysed by adapting a solid-phase microextraction gas chromatrography mass spectrometry method developed for white wine (Otero et al. 2002), with a limit of detection of 0.2 µg/L.

History of the health values

The current acceptable daily intake (ADI) for cyprodinil is 0.02 mg per kg body weight (mg/kg bw), based on a no-observed-effect level (NOEL) of 2.7 mg/kg bw/day from a long-term (2-year) dietary study in rats. The NOEL is based on an increased incidence of liver lesions in males at the next highest dose of 36 mg/kg bw/day. The ADI incorporates a safety factor of 100 and was established in 1994.

A health value has not been previously established by NHMRC.

Health considerations

Metabolism: Cyprodinil is rapidly absorbed via the gastrointestinal tract in rats. The parent compound is completely metabolised and excreted mainly as conjugated derivatives. These are excreted mainly in the urine within 48 hours.

Acute effects: Cyprodinil has low acute oral and dermal toxicity. It is a skin sensitiser in guinea pigs.

Short-term effects: In 1- to 3-month studies in mice, rats and dogs, the liver was the main target of toxicity, although most effects occurred only at very high dose levels. In mice, liver necrosis was observed at 257 mg/kg bw/day. In dogs, increased liver weights were observed at 46 mg/kg bw/day. Rats showed increased plasma cholesterol and phospholipid levels at 3 mg/kg bw/day, and effects on the thyroid and kidney at 19 mg/kg bw/day.

Long-term effects: Long-term dietary studies conducted in mice, rats and dogs showed the liver to be the main target organ of toxicity. Effects on the liver were noted at 600 mg/kg bw/day in mice (increased relative liver weight), at 36 mg/kg bw/day in male rats (spongiosis hepatitis) and at 446 mg/kg bw/day in dogs (pigmentation of hepatocytes). The lowest NOEL was 2.7 mg/kg bw/day in the rat study and this is the basis for the ADI.

Carcinogenicity: Based on long-term studies in mice, rats and dogs, there is no evidence of carcinogenicity for cyprodinil.

Genotoxicity: Cyprodinil is not considered to be genotoxic, based on in vitro and in vivo short-term studies.

Reproductive and developmental effects: A 2-generation reproduction study in rats did not produce any evidence of reproductive effects. Developmental studies in rats and rabbits showed effects on foetal development in rats only, at dose levels above the maternotoxic dose, which are well in excess of the likely level of human exposure.

Poisons Schedule: Cyprodinil is included in Schedule 5 of the Standard for the Uniform Scheduling of Medicines and Poisons No.1, 2010 (the Poisons Standard)(DoHA 2010). Current versions of the Poisons Standard should be consulted for further information.

Derivation of the health-based guideline

The health-based guideline of 0.09 mg/L for cyprodinil was determined as follows:

where:

  • 2.7 mg/kg bw/day is the NOEL based on a long-term (2-year) study in rats.

  • 70 kg is taken as the average weight of an adult.

  • 0.1 is a proportionality factor based on the assumption that 10% of the ADI will arise from the consumption of drinking water.

  • 2 L/day is the estimated maximum amount of water consumed by an adult.

  • 100 is the safety factor applied to the NOEL derived from animal studies. This safety factor incorporates a factor of 10 for interspecies extrapolation and 10 for intraspecies variation.

References

NOTE: The toxicological information used in developing this fact sheet is from reports and data held by the Department of Health, Office of Chemical Safety.

DoHA (2010) The Poisons Standard; Schedule 1-Standard for the Uniform Scheduling of Medicines and Poisons, Department of Health and Ageing, Commonwealth of Australia, Canberra.

Otero RR, Ruiz CY, Grande BC, Gandara JS (2002). Solid-phase microextraction-gas chromatographic-mass spectrometric method for the determination of the fungicides cyprodinil and fludioxonil in white wines. Journal of Chromatography A, 942(1-2):41-52.

Tomlin CD (ed) (2006). The Pesticide Manual: a world compendium, 14th Edition, British Crop Production Council, UK.

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Last updated 8 months ago

 0.09 mg/L = 2.7 mg/kg bodyweight/day x 70 kg x 0.1  2 L/day x 100 \text{ 0.09 mg/L } = \dfrac{\text{ 2.7 mg/kg bodyweight/day x 70 kg x 0.1 }}{\text{ 2 L/day x 100 }} 0.09 mg/L = 2 L/day x 100  2.7 mg/kg bodyweight/day x 70 kg x 0.1 ​